hla- b*1502 in iranian children with anticonvulsant drugs-induced skin reactions

objectives: anticonvulsant drugs can cause various forms of skin drug reactions, ranging from exanthema to severe blistering reactions. some studies have reported an association between hla-b*1502 allele and severe skin reactions. materials and methods: fifteen patients with severe skin reactions following treatment with anticonvulsant drugs (carbamazepine, lamotrigine, phenobarbital, primidone) and 15 controls (age matched epileptic patients taking similar anticonvulsants without drug eruption) were included in this study. genomic dna was extracted from peripheral blood of all patients and hla- b*1502 genotype was detected by real time pcr. results: none of the patients was positive for hla- b*1502, but two patients in control group had positive hla- b*1502. conclusion: the hla- b*1502 is not correlated with severe anticonvulsant drugs -induced skin reactions in iranian children.